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WBC anatomy and function

By ok learning

WBC Anatomy and Function:
v  Neutrophil:
§  Make up 60% to 70% of WBC
§  12-15 um in diameter
§  Nucleus 2-5 lobes(increase with cell age)
§  Fine granular cytoplasm
§  Phagocytic cell the engulf bacteria
§  Increase: stress, burns, bacterial infections
§  Decrease: Radiation exposure, B12 deficiency
v  Eosinophil:
§  Make up 2-5 % of WBC
§  Nucleus 2-4 lobes
§  Recruited to sites of inflammation
§  Function: Involved in allergy, parasitic infections
§  Contains: eosinophilic granules
§  Granules contain: major basic protein
§  Terminally differentiated
v  Basophil:
§  Make up 0% to 1% of WBC
§  8-10 um  in diameter
§  Cytoplasm filled with large deep blue-purple granules
§  Liberate heparin and histamines during allergic reactions
§  Intensify inflammatory response
§  Increase: Allergic reactions
§  Leukemia: cancers, hypothyroidism
§  Decrease: Pregnancy, ovulation, stress, hyperthyroidism
v  Lymphocytes:
§  Make up 30% to 40% of WBC
§  7-10 um  (small) and 10-13  (big)
§  Increase Viral infections and leukemic cell
§  Decrease: Prolonged illness, immunosuppression
v  Monocyte:
§  Make up 3-8 % of WBC
§  15- 25 um  in diameter
§  Nucleus is kidney -shaped
§  Phagocytic cells
§  Increase: Viral and fungal infection, tuberculosis, and some leukemic cells
§  Decrease: Bone marrow depression, treatment with cortisol




















































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