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Immunology

 Type of Immunology are:

Innate Immunity              Acquired Immunity
Structure&
Mechanism of
Actions
-Have external barriers
-1st line defense
-Very quick
-Exist from birth
-Have external barriers
-2st line defense
-Delay
-Activated after the exposure to micro-organisms
Specificity
-No specificity
-Only act against micro organism
-Doesn’t act against our own body
-Less potent
-More specific
-Act against micro- organism and other foreign subjects
-Sometimes act against our own body
-More potent
Receptors
Limited diversity
More diversity
Cells
Phagocytes and NK cells
Lymphocytes
Molecules
Natural antibodies presenting epithelial layers
Antibodies are present
Memory
No
yes
Exposure
Response will not change due to repeated exposure
Increased affinity and antibody levels with repeated exposure




v  Innate Immunity are:
·         External Immunity:
-Physical barriers: Skin, Mucosal, Natural reflexes
-Chemical barriers: Enzymes (Lysozyme in tears), HCL (gastric juice), Saliva
-Biological barriers: Non pathogenic bacteria
·         Internal Immunity are:
-Phagocytes: Monocytes(Blood), Microglial cell(Brain), Kuffer cell(Liver), Alveolar macrophages(Lungs), Osteoclast(Bone), Langerhan cells(Skin), Synovial A cells(Joint)
-Molecules: Acute phase proteins complements
v  Acquired Immunity are:
·         Humoral or B cell immunity
-Molecules involve:
B Lymphocytes: Memory cells, Plasma cells, Antibodies(Ig G, Ig A, Ig M, Ig D, Ig E)
-Involve Cytokines
-Complements involve(Antibody G,M involve)
·         Cells medicated or T cell Immunity
-Cells involve:
T Lymphocytes: T helper cells, Cytotoxic T cells, Memory cells











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